gp160, a tissue-specific marker for insulin-activated glucose transport.
نویسندگان
چکیده
منابع مشابه
Tissue-specific insulin resistance.
T he combination of abnormal glucose tolerance, central adiposity, dyslipidaemia, hypertension, and coronary artery disease is together referred to as the metabolic syndrome or the insulin resistance syndrome. A sedentary lifestyle, polygenic inheritance, and abnormal intrauterine programming are but some of the hypotheses put forward to explain the syndrome, the central underlying feature of w...
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Physical exercise promotes glucose uptake into skeletal muscle and makes the working muscles more sensitive to insulin. To understand the role of insulin receptor (IR) signaling in these responses, we studied the effects of exercise and insulin on skeletal muscle glucose metabolism and insulin signaling in mice lacking insulin receptors specifically in muscle. Muscle-specific insulin receptor k...
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The prevalence of type 2 diabetes mellitus is growing worldwide. Most forms of type 2 diabetes are polygenic with complex inheritance patterns strongly influenced by environmental factors. The specific gene defects are unknown, but they affect both insulin action and insulin secretion. Glucose homeostasis is maintained by the fine orchestration of insulin secretion and insulin action to promote...
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We recently demonstrated that epinephrine could inhibit the activation by insulin of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase) in skeletal muscle (Hunt DG, Zhenping D, and Ivy JL. J Appl Physiol 92: 1285-1292, 2002). Activation of PI3-kinase is recognized as an essential step in the activation of muscle glucose transport by insulin. We therefore ...
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The aim of our work was to investigate a possible role of protein kinase C (PKC) in insulin-stimulated glucose uptake in mouse skeletal muscle, and to search for a defect in PKC activation in insulin resistance found in obesity. In isolated soleus muscle of lean mice, insulin (100 nM) and 12-0-tetradecanoylphorbol 13acetate (TPA) (1 #M) acutely stimulated glucose uptake 3and 2-fold respectively...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.17.8017